Sublingual Delivery of Vaccines

نویسندگان

  • LOUISE B. LAWSON
  • LUCY C. FREYTAG
  • JOHN D. CLEMENTS
چکیده

Sublingual immunization, where the vaccine is placed directly under the tongue and absorbed through the sublingual mucosa, has the advantages of ease of delivery without the complication of oral administration or the safety concerns of intranasal vaccines. Sublingual vaccine delivery has been shown to induce development of humoral and cell mediated immunity in both the systemic and mucosal compartments to a variety of bacterial, viral, and protozoan antigens. Sublingual immunization represents and exciting breakthrough in vaccine delivery with great potential to overcome the barriers to effective mucosal immunization; this strategy holds great promise specially for vaccinating infants and children in developing countries.

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تاریخ انتشار 2010